![]() ![]() A comprehensive understanding of their inner workings thus requires linking these structural rearrangements to the different functional state transitions. ABC transporters undergo substantial conformational changes during substrate translocation. The substrates range from vitamins, steroids, lipids, and ions to peptides, proteins, polysaccharides, and xenobiotics. They function as molecular machines by coupling ATP binding, hydrolysis, and phosphate release to translocation of diverse substrates across membranes. “ Fncel-08-00161-g0001” By Annalisa Scimemi – (CC BY 2.ATP-binding cassette (ABC) transporters constitute one of the largest and most ancient protein superfamilies found in all living organisms. “ 1l7v opm” By Andrei Lomize – Own work (CC BY-SA 3.0) via Commons WikimediaĢ. “ ABC Transporter.” An Overview | ScienceDirect Topics. “ Solute Carrier Protein.” An Overview | ScienceDirect Topics.Ģ. So, this is the key difference between ABC and SLC transporters. ABC transporters assist in the movement of substances across a biological membrane through a primary active transport mechanism, while SLC transporters assist in the movement of substances across a biological membrane through secondary active transport and facilitative diffusion mechanisms. They are membrane proteins assisting in the movement of substances across a biological membrane. The below infographic presents the differences between ABC and SLC transporters in tabular form for side by side comparison.ĪBC and SLC transporters are two different types of carrier proteins. Furthermore, ABC transporters belong to a superfamily that has 49 members organized into 7 families, while SLC transporters belong to a superfamily that has 400 members organized into 66 families. Thus, this is the key difference between ABC and SLC transporters. What is the Difference Between ABC and SLC Transporters?ĪBC transporters are carrier proteins that assist in the movement of substances across a biological membrane through a primary active transport mechanism, while SLC transporters are carrier proteins that assist in the movement of substances across a biological membrane through secondary active transport and facilitative diffusion mechanisms. When dysfunctional, both transporters can cause diseases.They can transport substances through an active transport mechanism.Both are transport system superfamilies.ABC and SLC transporters are two different types of carrier proteins assisting in the movement of substances across a biological membrane.What are the Similarities Between ABC and SLC Transporters? This can also develop resistance to antibiotics. This is because the overexpression of ABC transporters can result in pumping out of chemotherapeutic drugs outside the cell faster than they can enter the cell. ABC transporters play a very critical role in the development of multi-drug resistance in cancer cells. Moreover, ABC transporters, specifically in prokaryotes, can also uptake certain substances such as a large variety of nutrients, biosynthetic precursors, trace metals, and vitamins. The substances that they transport include lipids and sterols, ions, small molecules, drugs, and large polypeptides. They transport a wide range of substances, mainly to the outside of a cell membrane or organelle. Summary – ABC vs SLC Transporters What are ABC Transporters?ĪBC transporters ( ATP binding cassette transporter) are carrier proteins that assist in the movement of substances across a biological membrane through a primary active transport mechanism. ABC vs SLC Transporters in Tabular FormĦ. Similarities – ABC and SLC Transportersĥ. They are classified into three classes: ABC transporters, P-type ATPases, and SLC transporters. Active transport mechanisms are primary active transport and secondary active transport. Passive transport mechanisms are diffusion and facilitated transport. These transporters use both active and passive transport mechanisms. Transporters or membrane transport/carrier proteins are highly specialized membrane-spanning proteins involved in the movement of ions, peptides, small molecules, lipids, and macromolecules across the biological membrane. The key difference between ABC and SLC transporters is that ABC transporters are carrier proteins assisting in the movement of substances across a biological membrane through primary active transport mechanism, while SLC transporters are carrier proteins assisting in the movement of substances across a biological membrane through secondary active transport and facilitative diffusion mechanisms. ![]()
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